摘要
The title compounds(5 a and 5 b) were synthesized from dehydroabietic acid and characterized by MS, IR, NMR and elemental analysis. The crystal structure of compound 5 a was determined by single-crystal X-ray diffraction. The compound is of monoclinic system, space group P21 with a = 8.0860(16), b = 14.011(3), c = 9.799(2) ?, β = 106.31(3)?, Z = 2, V = 1065.5(4) ?3, Mr = 431.48, Dc = 1.345 Mg/m3, S = 1.002, μ = 0.099 mm-1, F(000) = 460, the final R = 0.0617 and wR = 0.1532 for 1397 observed reflections(I > 2σ(I)). The preliminary antibacterial assay showed that compound 5 a exhibited considerable inhibitory activity against Bacillus subtilis, Staphylococcus aureus and Methicillin-resistant S. aureus(MRSA) with MIC values of 2～8 μg/mL.
作者
CHEN Hao
GENG Yi
WANG Shi-Fa
GU Wen
陈浩;耿艺;王石发;谷文(Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass, Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals, College of Chemical Engineering, Nanjing Forestry University)
基金
supported by the National Natural Science Foundation of China(31770616)
the Natural Science Foundation of Jiangsu Province(BK201516)
the Natural Science Foundation for Colleges and Universities in Jiangsu Province(17KJA220002)
Top-notch Academic Programs Project of Jiangsu Higher Education Institutions(PPZY2015C221)
a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)
