可膨胀水凝胶弹簧线圈与裸铂弹簧线圈栓塞颅内动脉瘤有效性及安全性的Meta分析

Hydrogel coils vs bare platinum coils in the treatment of intracranial aneurysms: a Meta analysis

目的比较可膨胀水凝胶弹簧线圈与裸铂弹簧线圈治疗颅内动脉瘤的有效性及安全性。方法系统检索Pubmed、Embase、Web of Science、Cochrane图书馆、中国知网及万方数据库自建库至2018年11月收录的关于使用水凝胶弹簧圈及裸铂弹簧圈治疗颅内动脉瘤的文献。制定文献的纳入与排除标准,筛选符合纳入标准的文献。采用RevMan5.3软件进行Meta分析。结果共纳入4篇文献,均为英文文献,样本量为1526例。Meta分析的结果表明,水凝胶线圈和裸铂线圈在术中完全栓塞动脉瘤(OR=0.89,95%CI:0.67～1.17,P=0.39)、术后18个月患者恢复情况(OR=1.35,95%CI:0.99～1.84,P=0.06)、所有并发症发生比例(OR=0.87,95%CI:0.69～1.10,P=0.25)方面差异均并无统计学意义,异质性较小(I2<50%,P>0.05)。结论同传统裸铂弹簧线圈相比,水凝胶弹簧线圈的有效性及安全性基本相同。

Objective To compare the efficacy and safety of hydrogel coils and bare platinum coils in the treatment of intracranial aneurysms by a Meta analysis. Methods Systematic retrieval of literature on the use of hydrogel coils and bare platinum coils in the treatment of intracranial aneurysms from the Pubmed, Embase, Web of Science, Cochrane Library, CNKI and Wanfang data from initiation of the databases to November 2018. The included studies were screened out strictly based on the criterion of inclusinon and exclusion. Revman 5.3 was used for Meta analysis. Results A total of 4 literature were included, all in English, with a sample of 1526 cases. The results of Meta analysis showed that there was no significant difference between hydrogel coil and bare platinum coil in embolization of aneurysms (OR=0.89, 95%CI: 0.67-1.17, P=0.39), recovery of patients 18 months after operation (OR=1.35, 95%CI: 0.99-1.84, P=0.06), and incidence of all complications (OR=0.87, 95%CI: 0.69-1.10, P=0.25), and with a relatively low heterogeneity (I2<50%, P>0.05). Conclusion Compared with bare platinum coils, hydrogel coils have similar efficacy and safety in in the treatment of intracranial aneurysms.