A20基因与NF-κB信号通路的研究进展

Research progress of A20 gene and NF-kappa B signaling pathway

NF-κB信号通路在慢性炎症中发挥着重要作用,在受到炎症因子的刺激下能够活化,加重炎症反应。NF-κB信号通路受到多种细胞因子的调控,A20基因作为NF-κB信号通路的一个负向调节因子,通过影响NF-κB信号通路中的某些基因,发挥炎症抑制作用,与某些炎症相关疾病的发生发展密切相关。

NF-κB signaling pathway plays an important role in the pathogenesis of chronic inflammation, which can be activated when stimulated by inflammatory factors, therefore, inflammatory response would be aggravated. The signaling pathway is regulated and controlled by various cytokines. As a kind of negative regulatory factor of the signaling pathway, A20 gene can suppress inflammation by exerting influences on some genes of the signaling pathway, which is closely related to occurrence and development of some inflammation-related diseases.