鼠神经生长因子治疗老年脑出血临床疗效及对患者血清NSE、hs-CRP、TNF-α、IL-8、MMP-9影响

Clinical effect, quality of life and effect of mousenerve growth factor on serum NSE, hs-CRP, TNF-α and IL-8,MMP-9 in elderly patients with cerebral hemorrhage

目的探析鼠神经生长因子(mNGF)治疗老年脑出血临床疗效及对患者血清神经元特异性烯醇化酶(NSE)、白介素(IL)-8、肿瘤坏死因子(TNF)-α、超敏C反应蛋白(hs-CRP)、金属基质蛋白酶(MMP)-9和生活质量影响。方法选取本院2017年5月至2018年6月收治的老年脑出血患者58例,双盲法数字随机分组,对照组(29例)给予降血压、营养细胞、依达拉奉及尼莫地平等常规用药,观察组(29例)则常规用药基础联合m NGF治疗,比较两组血清神经元特异性烯醇化酶(NSE)、炎性因子,评价临床疗效及生活质量。结果两组治疗4w后hs-CRP、TNF-α、IL-8、MMP-9、NSE、NIHSS评分、血肿量及水肿面积均明显低于治疗前(P<0.05),且观察组hs-CRP、TNF-α、IL-8、MMP-9、NSE、NIHSS评分、血肿量及水肿面积改善幅度明显优于对照组(P<0.05);观察组治疗有效率明显高于对照组(P<0.05)。两组治疗4w后Barthel指数、SIS评分均明显高于治疗前(P<0.05),且观察组Barthel指数、SIS评分提高幅度明显优于对照组(P<0.05)。结论老年脑出血患者采取m NGF治疗效果良好,可减轻炎症反应,血肿吸收及缓解水肿,促进神经功能恢复,改善生活质量。

Objective To investigate the clinical effect of mousenerve growth factor(mNGF)in the treatment of senile intracerebral hemorrhage and the serum neuron specific enolase(NSE),interleukin(IL)-8 and tumor necrosis factor(TNF)-α.Effects of hypersensitive C reactive protein(hs-CRP),metalloproteinase(MMP)-9 and quality of life.Method From May 2017 to June 2018,58 elderly patients with intracerebral hemorrhage were randomly divided into two groups.The control group(29 cases)was given lowering blood pressure,controlling intracranial pressure and nutritive cells.Edaravone and nimodipine were used routinely,while in the observation group(29 cases),routine therapy was combined with mNGF.The serum neuron-specific enolase(NSE),inflammatory factors were compared between the two groups,and the clinical efficacy and quality of life were evaluated.Results after 4 weeks of treatment,the scores of hs-CRP,TNF-α,-IL-8,MMP-9,NSE,NIHSS,hematoma volume and edema area in the two groups were significantly lower than those before treatment(P<0.05).The hs-CRP,TNF-α,IL-8,MMP-9,NSE,NNIHSS score,hematoma volume and edema area in the observation group were significantly better than those in the control group(P<0.05).The effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After 4 weeks of treatment,the Barthel index score of the two groups was significantly higher than that of the control group(P<0.05),and that of the observation group was significantly better than that of the control group(P<0.05).Conclusion mNGF can reduce inflammation,eliminate hematoma and edema,promote the recovery of nerve function and improve the quality of life in elderly patients with intracerebral hemorrhage.