1,25-二羟维生素D_3治疗糖尿病肾病疗效观察

Effect of 1,25-dihydroxyvitamin D_3 in the treatment of diabetic nephropathy

目的:探讨1,25-二羟维生素D_3治疗糖尿病肾病(DN)的疗效。方法:将60例DN患者随机分为试验组和对照组,每组30例。2组患者均接受常规降糖治疗,对照组患者口服厄贝沙坦150～300 mg/d;试验组患者口服厄贝沙坦150～300 mg/d,联合口服阿法骨化醇0.25μg,1次/d。记录并比较2组患者治疗前、后血糖化血红蛋白、肌酐等水平。结果:治疗3个月后试验组肌酐、尿N-乙酰-β-氨基葡萄糖苷酶、尿蛋白、血转化生长因子β_1均显著低于对照组(均P<0.05)。结论:1,25-二羟维生素D_3对DN患者有肾保护作用。

Objective:To study the effects of 1,25-dihydroxyvitamin D3 in the treatment of diabetic nephropathy(DN).Methods:Sixty patients with DN were selected and randomly divided into experimental group(EG,n=30)and control group(CG,n=30).All patients were given the routine hypoglycemic treatment.The control group was treated with irbesartan(150 to 300 mg/day).The experimental group was treated with irbesartan(150 to 300 mg/day),combined with oral administration of alfacalcidol(0.25μg,once every day).The blood HbA1 c,serum creatinine(Scr)and other biochemical test results before and after the treatement were recorded.Results:After treatment,the Scr,NAG,UPRO and blood TGF-β1 in the experimental group were significantly lower than those in the control group(P<0.05).Conclusion:1,25-dihydroxyvitamin D3 in the treatment of DN has the role to protect the kidney function.