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Effects of apoptosis on liver aging 被引量:1

Effects of apoptosis on liver aging
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摘要 As an irreversible and perennial process,aging is accompanied by functional and morphological declines in organs. Generally,aging liver exhibits a decline in volume and hepatic blood flow. Even with a preeminent regenerative capacity to restore its functions after liver cell loss,its biosynthesis and metabolism abilities decline,and these are difficult to restore to previous standards. Apoptosis is a programmed death process via intrinsic and extrinsic pathways,in which Bcl-2 family proteins and apoptosis-related genes,such as p21 and p53,are involved.Apoptosis inflicts both favorable and adverse influences on liver aging.Apoptosis eliminates transformed abnormal cells but promotes age-related liver diseases,such as nonalcoholic fatty liver disease,liver fibrosis,cirrhosis,and liver cancer. We summarize the roles of apoptosis in liver aging and age-related liver diseases. As an irreversible and perennial process,aging is accompanied by functional and morphological declines in organs. Generally,aging liver exhibits a decline in volume and hepatic blood flow. Even with a preeminent regenerative capacity to restore its functions after liver cell loss,its biosynthesis and metabolism abilities decline,and these are difficult to restore to previous standards. Apoptosis is a programmed death process via intrinsic and extrinsic pathways,in which Bcl-2 family proteins and apoptosis-related genes,such as p21 and p53,are involved.Apoptosis inflicts both favorable and adverse influences on liver aging.Apoptosis eliminates transformed abnormal cells but promotes age-related liver diseases,such as nonalcoholic fatty liver disease,liver fibrosis,cirrhosis,and liver cancer. We summarize the roles of apoptosis in liver aging and age-related liver diseases.
出处 《World Journal of Clinical Cases》 SCIE 2019年第6期691-704,共14页 世界临床病例杂志
基金 Supported by the National Natural Science Foundation of China,No.81660151,No.81660751,and No.81260504 the Science Foundation of the Science Commission of Jiangxi Province in China,No.20161BBG70067 Jiangxi Provincial Natural Science Foundation of China,No.20171BAB205085
关键词 APOPTOSIS LIVER AGING OXIDATIVE stress Caloric RESTRICTION CIRRHOSIS Apoptosis Liver aging Oxidative stress Caloric restriction Cirrhosis
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