男性乳腺癌22例临床病理特征及生存分析

Clinicopathological Features and Survival Analysis of 22 Cases of Male Breast Cancer

目的探讨男性乳腺癌(MBC)患者的临床病理特征及人表皮生长因子受体2(Her-2)、肿瘤细胞核抗原Ki-67的表达对男性乳腺癌预后的影响。方法对南昌大学第一附属医院2007年5月至2017年3月收治的22例MBC患者的临床病理特征及生存资料进行回顾性分析。结果 22例MBC患者年龄48～80岁(中位年龄68岁),首诊症状为无痛性乳晕区肿块,首诊时病期一般较晚。MBC病理类型以浸润性导管癌多见,雌激素受体(ER)及孕激素受体(PR)阳性率均为88.9%。MBC患者的Her-2高表达是影响其预后的重要因素(P=0.018),而Ki-67的表达可能与其预后无关(P=0.515)。结论 MBC有其独特的临床病理特点;Her-2高表达可能预示MBC患者较差的预后。

Objective To discuss the clinicopathologic features of male breast cancer(MBC),and to investigate the effects of human epidermal growth factor receptor 2(Her-2) and tumor nuclear antigen Ki-67 expression on the prognosis of MBC. Methods The clinicopathologic features and survival data of 22 MBC patients treated from May 2007 to March 2017 in the First Affiliated Hospital of Nanchang University were retrospectively analyzed. Results MBC patients rangedin age from 48 to 80 years(median,67 years),and presented with painless areola mass at initial diagnosis.Invasive ductal carcinoma was the most common pathological type of MBC.The positive rates of estrogen receptor(ER+) and progesterone receptor PR(+) were 88.9%.The high expression of Her-2 was an important factor affecting the prognosis of MBC patients( P =0.018).However,Ki-67 expression may not be related to MBC prognosis( P =0.515). Conclusion MBC has unique clinicopathological features.Her-2 over-expression may indicate a poor prognosisin MBC patients.