自噬对肾纤维化影响的研究进展

Research Progress in Effect of Autophagy on Renal Fibrosis

自噬是通过溶酶体途径降解内源性细胞蛋白聚集物和受损细胞器,以维持细胞稳态和能量生成的一种"自食"过程。肾纤维化是终末期肾脏疾病的最终病理表现,在急性和慢性肾脏疾病的实验模型中,自噬已被证实对肾细胞存活至关重要,自噬可能具有促进和预防肾纤维化的双重调节作用。目前,国内外关于肾纤维化的治疗研究尚未取得较大进展,该文将自噬对肾纤维化影响的研究作一总结,可能为预防和延缓肾纤维化进展提供新的治疗思路。

Autophagy is a “self-eating” process by which endogenous protein aggregates and damaged organelles are degraded through lysosome pathway to maintain cell homeostasis and energy production.Renal fibrosis is the final pathological manifestation in the end-stage renal disease.In experimental models of acute and chronic kidney disease,autophagy has been shown to be crucial for the survival of kidney cells.Autophagy may play a dual regulatory role in promoting and preventing renal fibrosis.At present,little progress has been made in the treatment of renal fibrosis in China and abroad.This article summarizes the effect of autophagy on renal fibrosis,which may provide a new way to prevent and delay the progression of renal fibrosis.