摘要
Cancer cachexia is a complex multifactorial syndrome that has a substantial impact on the quality of life of cancer patients. Although some treatment options exist to counteract cachexia, very few options counteract sarcopenia (loss of muscle mass). HMB may be a viable component in multi-modal approaches targeting treatment of cancer cachexia/sarcopenia. Evidence suggests that HMB promotes myogenic events, suppresses proteasome activity, and activates protein synthesis. HMB also represses inflammation, reduces tumor growth, and increases lifespan.
