美托洛尔联合曲美他嗪治疗冠心病心力衰竭效果分析

Analysis of the effect of Metoprolol combined with Trimetazidine in the treatment of heart failure of coronary heart disease

目的探讨美托洛尔联合曲美他嗪治疗冠心病心力衰竭的临床效果。方法选取2015年1月～2018年1月我院收治的60例冠心病心力衰竭患者,按照随机抽签方式将其分为对照组和观察组,每组各30例。对照组患者给予常规治疗,观察组给予美托洛尔联合曲美他嗪治疗,观察两组患者的临床总有效率、治疗前后左心室舒张末期内径(LVEDD)、左室射血分数(LVEF)、左心室收缩末期内径(LVESD)指标。结果观察组的临床总有效率(93.33%)明显高于对照组(70.00%),差异有统计学意义(P<0.05)。两组患者治疗前的LVEDD、LVEF、LVESD指标比较,差异无统计学意义(P>0.05)。观察组治疗后的LVEF明显高于治疗前及对照组,LVEDD、LVESD指标明显低于对照组及治疗前,差异有统计学意义(P<0.05)。结论采取美托洛尔联合曲美他嗪治疗冠心病心力衰竭,能有效改善患者心脏功能,临床疗效理想。

Objective To investigate the clinical effect of Metoprolol combined with Trimetazidine in the treatment of heart failure of coronary heart disease. Methods A total of 60 patients with heart failure of coronary heart disease admitted to our hospital from January 2015 to January 2018 were selected and divided into the control group and the observation group according to random lottery, 30 cases in each group. Patients in the control group were given routine treatment, while patients in the observation group were given Metoprolol combined with Trimetazidine. The clinical efficacy, left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF) and left ventricular end systolic diameter (LVESD) were measured and observed before and after treatment in the two groups. Results The clinical total effective rate in the observation group was 93.33%, which was significantly higher than that in the control group (70.00%), and the difference was statistically significant (P<0.05). Before treatment, there were no significant differences in LVEDD, LVEF and LVESD between the two groups (P>0.05). After treatment, the level of LVEF of the observation group was significantly higher than that before treatment and the control group, while the level of LVEDD and LVESD of the observation group were significantly lower than those before treatment and the control group, and the difference was statistically significant (P<0.05). Conclusion Metoprolol combined with Trimetazidine in the treatment of heart failure of coronary heart disease can effectively improve the patient′s heart function, the clinical effect is ideal.