天麻钩藤饮加减治疗阴虚阳亢证高血压患者的效果

Effect of Tianma Gouteng Decoction in the treatment of hypertension patients with the pattern of yin deficiency and yang hyperactivity

目的探讨阴虚阳亢证高血压采取天麻钩藤饮加减治疗的效果。方法选取2017年10月5日～2018年6月21日武汉市华润武钢总医院收治的64例阴虚阳亢证高血压患者作为研究对象,采取动态随机分组法将其分为对照组与观察组,每组各32例。对照组患者采取常规治疗,观察组患者予以天麻钩藤饮加减治疗。比较两组患者治疗前后的血压、生化指标(醛固酮、血管紧张素Ⅱ、肾素)及不良反应发生情况。结果两组患者治疗前的血压比较,差异无统计学意义(P>0.05);两组患者治疗后的舒张压、收缩压均低于治疗前,差异有统计学意义(P<0.05);观察组患者治疗后的舒张压、收缩压分别为(78.72±2.28)、(119.43±3.38)mmHg,均低于对照组的(90.13±5.05)、(135.37±2.26)mmHg,差异有统计学意义(P<0.05)。两组患者治疗前的生化指标比较,差异无统计学意义(P>0.05);两组患者治疗后的醛固酮、血管紧张素Ⅱ、肾素水平均低于治疗前,差异有统计学意义(P<0.05);观察组患者治疗后的醛固酮、血管紧张素Ⅱ、肾素水平分别为(280.11±3.74)ng/L、(108.14±5.25)ng/L、(1.58±0.39)ng/ml,均低于对照组[(309.87±4.04)ng/L、(119.70±4.38)ng/L、(4.11±0.55)ng/ml],差异有统计学意义(P<0.05)。观察组患者的不良反应总发生率为3.13%,显著低于对照组的21.88%,差异有统计学意义(P<0.05)。结论阴虚阳亢证高血压采取天麻钩藤饮加减治疗,效果显著,可有效控制病情发展。

Objective To study the effect of Tianma Gouteng Decoction in the treatment of hypertension patients with the pattern of yin deficiency and yang hyperactivity. Methods A total of 64 cases of hypertensive patients with the pattern of yin deficiency and yang hyperactivity admitted to Wuhan General Hospital of WISCO from October 5, 2017 to June 21, 2018 were selected as the research subjects, and they were divided into the control group and the observation group by dynamic random grouping method, with 32 cases in each group. Patients in the control group were treated with conventional method, and patients in the observation group were treated with Tianma Gouteng Decoction. Blood pressure and biochemical indicators (aldosterone, angiotensin II, renin) before and after treatment and adverse reactions in the two groups were compared. Results There was no significant difference in blood pressure between the two groups before treatment (P>0.05). The diastolic blood pressure and systolic blood pressure of the two groups after treatment were lower than those before treatment, and the differences were statistically significant (P<0.05). The diastolic blood pressure and systolic blood pressure after treatment of the observation group were (78.72±2.28) and (119.43±3.38) mmHg respectively, which were lower than those of the control group ([90.13±5.05],[135.37±2.26]) mmHg, and the differences were statistically significant (P<0.05). There were no significant differences in biochemical indicators between the two groups before treatment (P>0.05). The levels of aldosterone, angiotensin II and renin in the two groups after treatment were lower than those before treatment, and the differences were statistically significant (P<0.05). The levels of aldosterone, angiotensin II and renin after treatment in the observation group were (280.11±3.74) ng/L,(108.14±5.25) ng/L, and (1.58±0.39) ng/ml respectively, which were lower than those in the control group ([309.87±4.04] ng/L,[119.70±4.38] ng/L,[4.11±0.55] ng/ml), and the differences were statistically significant (P<0.05). The total incidence rate of adverse reactions was 3.13% in the observation group, which was significantly lower than the 21.88% in the control group, and the difference was statistically significant (P<0.05). Conclusion The effect of Tianma Gouteng Decoction is remarkable in the treatment of hypertension patients with the pattern of yin deficiency and yang hyperactivity, which can effectively control the development of the disease.