应激与肠易激综合征相关性研究

Relationship between stress and irritable bowel syndrome

肠易激综合征(irritable bowel syndrome,IBS)是一种以脑-肠互动异常为核心的功能性肠病,在我国和世界范围内发病率高,严重影响患者生活质量。IBS与应激密切相关,患者多合并急慢性应激状态与精神障碍共病。应激通过塑造内脏高敏感性、促进肠道低度炎症和干扰肠道菌群等机制参与IBS的发生与发展。本文就应激在IBS发病中的作用及相关临床干预方法作一概述,为IBS的预防、治疗和后续研究提供理论依据。

Irritable bowel syndrome(IBS)is a kind of functional bowel diseases centered on brain-gut interaction disorder.Of great morbidity nationwide and worldwide,IBS affects the quality of life of patients immensely and extensively.IBS is closely related to stress,and acute or chronic stress states and psychiatric co-morbidities are commonly seen in IBS patients.Stress promotes the onset and development of IBS through building up visceral hypersensitivity,deteriorating intestinal low-grade inflammation and interfering with intestinal microbiota.Here,the mechanisms of stress involved in IBS and clinical treatments in relevance were reviewed,hoping to collect theoretical bases for IBS prevention,treatment and researches in future.