大黄素对糖尿病大鼠血糖和周围神经病变的影响

Efficacy of emodin on blood glucose and peripheral neuropathy in diabetic rats

目的:观察大黄素对链尿佐菌素诱导大鼠糖尿病血糖和周围神经病变的影响及可能作用机制。方法:链脲佐菌素诱导糖尿病大鼠模型,随机分为模型组和治疗组,每组10只。另设对照组大鼠10只。三组连续给药8周。观察药物对糖尿病大鼠空腹血糖、糖耐量、坐骨神经山梨醇水平以及脊髓致炎细胞因子水平。结果:大黄素可显著抑制脊髓致炎细胞因子肿瘤坏死因子-α(TNF-α)和白介素1β(IL-1β)水平,明显降低糖尿病大鼠血糖和各时间点血糖曲线下面积(P <0.01);治疗组坐骨神经山梨醇水平明显低于模型组(P <0.01)。结论:大黄素对糖尿病大鼠周围神经病变具有明显的改善作用,其作用机制可能与改善体内山梨醇代谢和抑制脊髓致炎细胞因子水平有关。

Objective:To observe possible mechanism and efficacy of emodin on blood glucose and peripheral neuropathy in STZ diabetic rats.Methods:STZ diabetic rats were divided into the model group and the treatment group,10 rats per group.In addition,the control group was established with 10 rats.All groups were administered for 8 weeks.Results:Emodin can significantly inhibit the levels of inflammatory cytokines TNF-αand IL-1βin the spinal cord,significantly reduce the blood glucose level and the area under the blood glucose curve at each time point in diabetic rats(P<0.01);the level of sciatic nerve sorbitol was significantly lower than that in the model group(P<0.01).Conclusion:Emodin has a significant improvement effect on peripheral neuropathy in diabetic rats,and the mechanism may be related to the improvement of sorbitol metabolism and inhibition of spinal cord proinflammatory cytokine levels.