阿托伐他汀在中重度慢性持续期支气管哮喘治疗中的效果

Effects of atorvastatin on moderate to severe chronic persistent bronchial asthma

目的:研究阿托伐他汀在中重度慢性持续期支气管哮喘治疗中的效果。方法:本次研究选取的研究对象为2017年1月-2018年4月期间在我院进行治疗的中重度慢性持续期支气管哮喘患者,将97例患者遵循随机分组原则分为两组,48例对照组患者予以甲强龙治疗,49例观察组患者在其基础上加用阿托伐他汀治疗。将两组患者的哮喘症状情况、哮喘控制测试评分、炎症细胞因子指标进行比对。结果:观察组中重度慢性持续期支气管哮喘患者治疗后的日间症状评分、夜间症状评分与对照组相比较差异无统计学意义,哮喘控制测试评分高于对照组(P <0.05),但两组患者治疗后的哮喘症状评分相较于治疗前改变较大(P <0.05);观察组治疗后的炎症细胞因子指标数据均低于对照组(P <0.05)。结论:阿托伐他汀能够促进中重度慢性持续期支气管哮喘患者哮喘症状的改善和减轻炎症反应。

Objective:To study the effects of atorvastatin on moderate to severe chronic persistent bronchial asthma.Methods:97 patients were randomly divided into two groups.48 patients in the control group were treated with methylprednisolone;and 49 patients in the observation group were given atorvastatin.The asthma symptom score,asthma control test score,inflammatory factor level in two groups were compared.Results:The daytime symptom scores and nocturnal symptom scores in the observation group were not significantly different from the control group.The asthma control test score was higher than the control group(P<0.05).But the asthma symptom scores in the two groups were significantly higher than before treatment(P<0.05).The level of inflammatory factors in the observation group was lower(P<0.05).Conclusion:Atorvastatin on moderate to severe chronic persistent bronchial asthma was effective.