柴胡升降散治疗亚急性甲状腺炎的临床观察

Clinical observation on treating subacute thyroiditis with Chaihu Shengjiang San

目的:观察柴胡升降散治疗亚急性甲状腺炎的临床疗效。方法:选取符合纳入标准的108例亚急性甲状腺炎的患者,按随机数字表法分为治疗组与对照组,各54例,对照组予以泼尼松片治疗,治疗组予以柴胡升降散治疗;两组疗程均为8周;观察两组患者治疗前后临床疗效、中医证候积分、炎症指标、甲状腺功能指标及B超甲状腺肿块大小变化情况、不良反应情况;停药后随访半年,观察两组复发率、甲状腺功能减退症发生率。结果:治疗组总有效率达92.59%,优于对照组的66.70%(P<0.05);治疗组在改善中医证候积分方面优于对照组(P <0.01);治疗组治疗后炎症指标、甲状腺功能及B超甲状腺肿块大小变化情况与对照组比较差异无统计学意义(P> 0.05);治疗组不良反应发生率为3.70%,对照组不良反应发生率为22.20%;治疗组在复发和甲状腺功能减低发生方面明显好于对照组(P <0.05)。结论:柴胡升降散治疗亚急性甲状腺炎的临床疗效可靠,并能明显改善患者的临床症状及体征,不良反应很少,在减少病情复发和甲状腺功能减低方面具有优势,值得临床推广及进一步研究。

Objective:To observe the clinical efficacy of Chaihu Shengjiang San(柴胡升降散)on subacute thyroiditis.Methods:108 patients were divided into the treatment group and control group,54 cases in each.The control group was treated with prednisone tablets.The treatment group was treated with Chaihu Shengjiang San,for 8 weeks.The clinical efficacy,TCM syndromes scores,inflammatory indexes,thyroid function index,lump size changes and adverse reaction in two groups were observed.Follow up for six months after withdrawal,the recurrence rate and the incidence of hypothyroidism in the two groups were observed.Results:The total efficiency was 92.59% in the treatment group,better than 66.70% in the control group(P<0.05).The improvement of TCM syndromes in the treatment group was superior to the control group(P<0.01).The inflammatory index after treatment,thyroid function index and lump size changes in two groups were did not show difference(P>0.05).The incidence of adverse reactions was 3.70% in the treatment group and was 22.20% in the control group.The recurrence and reduction of thyroid function in the treatment group were significantly better than the control group(P<0.05).Conclusion:Chaihu Shengjiang San shows reliable clinical efficacy,can obviously improve the clinical symptoms and signs,with fewer adverse reactions,can reduce recurrence of the disease and thyroid function,and is worthy of clinical promotion and further study.