摘要
乳腺癌耐药蛋白属于三磷酸腺苷结合转运蛋白G超家族成员2(ATP-binding cassette superfamily G member 2, ABCG2),其作为药物排出泵,可以降低细胞内药物的浓度,保护细胞免受有毒物质的侵害.它保护正常细胞,但同时使肿瘤细胞对各种抗肿瘤药物产生耐药性,影响化疗效果.本文综述ABCG2的生理功能、表达影响因素以及与消化道肿瘤的关系与作用,为消化道肿瘤的临床基础研究提供参考.
The breast cancer resistance protein,also known as ABCG2,is a member of the drug efflux membrane transporters.As a drug discharge pump,ABCG2 can reduce the concentration of intracellular drugs and protect cells from toxic substances.ABCG2 is not only able to protect normal cells,but also to influence the chemotherapy effect by making tumor cells resistant to various anti-cancer drugs.In order to provide a reference for the basic and clinical research of gastrointestinal tumors,we review the physiological function of ABCG2,factors affecting ABCG2 expression,and its relationship with gastrointestinal tumors.
作者
邓凤莲
黎梨
黄赞松
Feng-Lian Deng;Li Li;Zan-Song Huang(Guangxi Clinical Medical Research Center of Hepatobiliary Diseases,the Affiliated Hospital of Youjiang Medical College for Nationalities,Baise 533000,Guangxi Zhuang Autonomous Region,China;Graduate School of Youjiang Medical College for Nationalities,Baise 533000,Guangxi Zhuang Autonomous Region,China)
出处
《世界华人消化杂志》
CAS
2019年第6期395-401,共7页
World Chinese Journal of Digestology
基金
广西自然科学基金资助项目
No.桂财教2014GXNSFAA118143
广西科技基地与人才专项(广西肝胆疾病临床医学研究中心研究课题)
No.桂科AD17129035
2017年度广西医药卫生自筹经费计划课题
No.桂卫Z20170224~~
关键词
三磷酸腺苷结合转运蛋白G超家族成员2
多药耐药
消化道肿瘤
Adenosinetriphosphate-binding cassette transporter protein G2 gene
Multidrug resistance
Gastrointestinal tumor
