回归分析胎儿MRI肺容积预期值

Regression analysis of expected fetal lung volume on MRI

目的建立大样本量、孕周分布均衡的中国胎儿肺容积(FLV)预期值回归方程。方法采集457胎胎龄18～39周胸部正常胎儿产前MRI,在单次激发快速自旋回波序列轴位图像上测量FLV。对采集到的样本数据进行回归分析,根据拟合度及检验结果确定回归模型,并得出基于孕周的FLV预期值回归方程。结果 457胎胎儿平均孕周为(29.44±4.61)周,其中孕周≤28周胎儿占43.11%(197/457)。基于MRI测量FLV值为9.47～131.48 ml,平均(50.78±23.76)ml。回归分析所得方程为FLV预期值=0.004g^(2.76)(g为孕周,R^2=0.845,P<0.001)。结论本研究所得的FLV预期值回归方程简便实用,适用于大多数产前检查,有助于国内开展胎儿肺产前评估相关研究。

Objective To establish domestic expected fetal lung volume (FLV) regression formula according to gestational week (GW) with large sample and data distributed evenly. Methods Prenatal MRI of 457 fetuses from 18 to 39 gestational weeks with normal chest was collected.FLV was measured on the axial images of single shot fast spin echo sequence.All FLV data were used for regression analysis.The regression model was determined according to the degree of fitting and test results,and the expected FLV regression formula based on GW was obtained. Results The mean GW of 457 fetuses was (29.44±4.61) weeks.There were 43.11%(197/457) fetuses at 28 weeks and below.FLV based on MRI measurement ranged from 9.47 ml to 131.48 ml,mean (50.78±23.76) ml.The final regression formula was expected FLV=0.004g 2.76 (g=GW, R 2=0.845, P <0.001). Conclusion The final regression formula of expected FLV is simple,practical and applicable to most fetuses,and is helpful to the research on prenatal assessment of domestic fetuses lung.