趋磁细菌磁小体及其相关MRI报告基因分子影像学研究

Molecular imaging for magnetotactic bacterial magnetosomes and related MRI reporter genes

趋磁细菌受基因调控形成纳米Fe_3O_4颗粒——磁小体,自带天然脂性包膜,其独特结构与特性受到分子影像学研究的重视,特别是纯化磁小体在磁性粒子成像中的应用和磁小体相关调控基因在MRI报告基因的分子影像学中的应用。相关研究逐年增多,但有关MRI报告基因的研究尚处于初级阶段。本文对趋磁细菌磁小体及其相关基因在MRI报告基因的分子影像学研究进行综述。

Magnetotactic bacteria encode iron nanoparticles-magnetosomes,which are regulated by a group of genes,have organelle-like structures.Their unique structures have received much attention in recent years due to the distinctive properties,including applications of purified magnetosomes in magnetic particles imaging and of magnetosome-associated regulatory genes in molecular imaging as MRI reporter genes.Although the research on magnetosomes has been increasing in recent years,its application as MRI reporter gene is still in its infancy.Molecular imaging studies of magnetosomes and related genes as MRI reporter genes were reviewed in this article.