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姑息手术联合FOLFOX辅助化疗对老年中晚期直肠癌患者生存率及生活质量的影响 被引量:1

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摘要 目的探究姑息手术联合FOLFOX辅助化疗对老年中晚期直肠癌患者生存率及生活质量的影响。方法选取2010年10月~2012年5月到我院进行治疗的老年中晚期直肠癌患者64例。采取随机方式,分为观察组(n=32)和对照组(n=32)。对所有患者进行姑息手术治疗;观察组患者在此基础上,进行FOLFOX辅助化疗。治疗后对患者进行随访,比较两组患者的1年、2年、5年内生存率以及生活质量。结果治疗后,观察组患者1年(78.13%)、2年(53.13%)、5年生存率(21.88%)均明显高于对照组患者(56.25%)(31.25%)(6.25%)。且中位生存期(26.88个月)大于对照组(14.76个月),差异显著(P<0.05)。观察组治疗前(95.23±8.91)后(46.27±7.82)质量评分降低幅度较大,有统计学意义(P<0.05);对照组治疗前(93.74±9.15)后(79.20±7.28)呈下降趋势,但无统计学意义(P>0.05)。治疗后,观察组患者生存质量评分明显低于对照组患者(P<0.05)。结论姑息手术联合FOLFOX辅助化疗能够提高老年中晚期直肠癌患者的生存率,提高其生活质量,应加强临床推广和应用。
出处 《海峡药学》 2019年第3期184-186,共3页 Strait Pharmaceutical Journal
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