植物中介因子复合体亚基尾部模块研究进展

Research Progress on Mediator Complex Tail Module in Plant

中介因子复合体是当今分子生物学领域中热门的研究方向。复合体被分为头部、中部、尾部和细胞周期素依赖性激酶4个模块部分。其中尾部模块能直接和转录激活因子结合并调控该基因的表达,是中介因子复合体发挥调控功能的重要模块。本文系统阐述了植物体内尾部模块中各个亚基(主要为MED16、MED25)的调控作用机制,并进行了展望,旨在为亚基新功能的开发提供参考。

Intermediate factor complex is a hot research direction in the field of molecular biology.The complex is divided into four modules: head,middle,tail and cyclin-dependent kinase.The tail module can directly bind to transcription activator and regulate the expression of the gene.It is an important module for the mediator complex to play a regulatory role.In this paper,the regulatory mechanism of each subunit (mainly MED16 and MED25) in the tail module of plant was systematically described,and the prospect was given,in order to provide reference for the development of new functions of the subunit.