10925例儿童25-羟基维生素D_3不足及缺乏情况分析

Analysis of insufficiency and deficiency of 25-Hydroxyvitamin D_3 in 10 925 children

目的调查1个月～16岁10 925例儿童25-羟基维生素D_3(25-OH-D_3)不足及缺乏情况,为维生素缺乏症的防控和合理补充维生素D提供重要依据。方法采用酶联免疫法对2016年1月至12月在首都医科大学附属北京儿童医院保健科常规体检的1个月～16岁儿童10 925例进行全血25-OH-D_3检测,并对不同年龄、不同性别及全年各季节的儿童25-OH-D_3不足及缺乏率进行分析。结果 10 925例儿童中,不同季节比较中夏季和冬季儿童25-OH-D_3不足及缺乏率高于春、秋季;不同年龄组儿童之间25-OH-D_3不足及缺乏率比较,1月～1岁及>6岁以上儿童25-OH-D_3不足及缺乏率高于其他年龄组儿童,差异有统计学意义;不同年龄组男童和女童之间25-OH-D_3不足及缺乏率比较无统计学意义。结论在1月～1岁及>6岁儿童中25-OH-D_3普遍不足及缺乏,应加强<1岁和>6岁儿童的维生素D制剂的补充及合理安排户外照射时间,>6岁以上儿童增加户外运动时间,定期监测25-OH-D_3的水平,合理指导对儿童的维生素D制剂的补充。

Objective To provide important proof for preventing and controlling vitamin D deficiency,the insufficiency and deficiency of 25-Hydroxyvitamin D 3 (25-OH-D 3) in 10 925 children aged 1 month to 16 years old were investigated. Methods Enzyme-linked immunosorbent assay (ELISA) was used to detect the 25-OH-D 3 levels in the whole blood of 10 925 children aged 1 month to 16 years old from January 2016 to December 2016 in Beijing Children's Hospital.The effects of age,gender and season on the insufficiency and deficiency rate of 25-OH-D 3 in children were analyzed. Results The insufficiency and deficiency rates of 25-OH-D 3 in summer and winter were higher than in spring and autumn ( P <0.05).The insufficiency and deficiency rates were higher in the children aged 1 month to 1 year old and > 6 years old than in other age groups ( P <0.05).There was no significant statistically difference in the 25-OH-D 3 deficiency between different genders. Conclusion The 25-OH-D 3 was insufficient and deficient generally in the children aged 1 month to 1 year old and over 6 years old.The supplementation of vitamin D should be strengthened and the outdoor irradiation time should be increased in these children.The children over 6 years old should increase outdoor sports,the level of 25-OH-D 3 should be monitored regularly,and the supplementation of vitamin D should be guided reasonably.