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TP73-AS1在肿瘤中的表达及调控作用 被引量:6

Expression and regulatory effect of P73 antisense RNA 1T in tumors
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摘要 随着高通量测序技术的发展,成千上万种长链非编码RNA(long non-coding RNA,lncRNA)进入人们的视野。lncRNA是一类长度超过200个核苷酸并缺少开放阅读框的不具备蛋白质编码功能的RNA [1-2]。研究发现lncRNA参与诸多生物学进程的关键步骤,包括染色质重塑、基因转录、转录后调节和蛋白质翻译等[3-5]。LncRNA机制的不断被阐明,也为肿瘤的研究提供了新的可能。LncRNA在多种肿瘤的增殖、迁移侵袭和抗凋亡等生物学特性中发挥重要作用,可通过转录、表观遗传调节、印迹、剪接和亚细胞转运等参与肿瘤的发生发展。为让患者获得更好的治疗效果,研究者们长期致力于寻找各种有效的肿瘤标记物,其中lncRNA在恶性肿瘤诊断和治疗中就具有重要的潜在应用价值[6]。 The discovery of abundant new long non-coding RNAs(lncRNAs) and extensive investigation of their roles in various diseases have been reported, especially in cancers. The lncRNA P73 antisense RNA1T(TP73-AS1) is involved in dysregulation of cell signaling and closely correlated with cancer development, progression, and response to therapy. This review is a brief update of the current knowledge related to the role of TP73-AS1 in cancer-associated molecular pathways and pathophysiology, and possible determinants for TP73-AS1 to function as a biomarker, aiming to stimulate the basic investigation of TP73-AS1 as well as its translation to clinical applications.
作者 王嘉新 胡增涛 关沧海 孙东升 王微娜 姜兴明 WANG Jia-xin;HU Zeng-tao;GUAN Cang-hai;SUN Dong-sheng;WANG Wei-na;JIANG Xing-ming(The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China)
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2019年第4期764-768,共5页 Chinese Journal of Pathophysiology
基金 国家自然科学基金资助项目(No.81602088) 中国博士后科学基金资助项目(No.2017M621305) 黑龙江省博士后科学基金资助项目(No.LBH-Z16096) 黑龙江省卫生计生委科研课题(No.2016-049) 哈尔滨医科大学创新科学研究基金资助项目(No.2016LCZX09)
关键词 长链非编码RNA 肿瘤 TP73-AS1 调控机制 Long non-coding RNA Tumor TP73-AS1 Regulatory mechanism
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