晚期结直肠癌患者TNF-α及FoxM1水平与临床病理特征的关系分析

Relationship between TNF-α and FoxM1 Levels and Clinical and Pathological Features in Patients with Advanced Colorectal Cancer

目的:分析晚期结直肠癌患者肿瘤坏死因子-α(TNF-α)及叉头框M1基因(FoxM1)水平和临床病理特征的关系。方法:回顾性分析60例资料完整、病理诊断明确的晚期结直肠癌患者的临床资料,经手术获取癌灶组织与癌旁健康组织。使用免疫组化方式对癌灶组织与癌旁健康组织TNF-α及FoxM1阳性率进行检测。结果:结直肠癌灶组织中TNF-α及FoxM1阳性率均高于癌旁健康组织,差异均有统计学意义(P<0.05);晚期结直肠癌分化程度低、突破浆膜层、有淋巴结转移患者TNF-α及FoxM1阳性率高于分化程度高+中、未突破浆膜层、无淋巴结转移患者,差异均有统计学意义(P<0.05);在60例晚期结直肠癌灶组织中,TNF-α和FoxM1阳性表达率呈正相关(r=0.416,P<0.01)。结论:在晚期结直肠癌灶组织中,TNF-α及FoxM1表达水平高,两者呈正相关。结直肠癌的发生、发展过程可能对两者具有促进作用,两者联合检测可为结直肠癌病变性质的判断提供参考,为晚期结直肠癌的靶向治疗提供理论依据。

Objective:To analyze the relationship between tumor necrosis factorα(TNF-α)and fork frame M1(FoxM1)levels and clinical and pathological features in patients with advanced colorectal cancer.Method:The clinical data of 60 patients with advanced colorectal cancer with complete clinical data and definite pathological diagnosis were retrospectively analyzed.Cancer focus and adjacent healthy tissues were obtained by operation.The positive rates of TNF-αand FoxM1 in cancer tissue and adjacent healthy tissue were detected by immunohistochemistry.Result:The positive rates of TNF-αand FoxM1 in colorectal cancer tissues were higher than those in adjacent healthy tissues,there were statistical significance(P<0.05).The positive rates of TNF-αand FoxM1 in advanced colorectal cancer tissues with low differentiation,serosa breakthrough and lymph node metastasis were higher than those in patients with high+middle differentiation,no serosa breakthrough and no lymph node metastasis,there were statistical significance(P<0.05).The positive expression rates of TNF-αand FoxM1 were positively correlated(r=0.416,P<0.01).Conclusion:TNF-αand FoxM1 are highly expressed in advanced colorectal cancer tissues,and they are positively correlated.The occurrence and development of colorectal cancer may play a role in promoting the two.The combined detection of the two can provide a reference for judging the nature of colorectal cancer lesions and provide a theoretical basis for targeting treatment of advanced colorectal cancer.