生殖道B族链球菌感染对妊娠晚期孕妇妊娠结局及新生儿的影响

Effect of Genital Tract B Streptococcal Infection on Pregnancy Outcome and Neonates in Pregnant Women in Late Pregnancy

目的:探讨生殖道B族链球菌感染对妊娠晚期孕妇妊娠结局及新生儿的影响。方法:选择2017年7月-2018年7月于龙华区某医院妇产科行产前检查的孕35周以上的孕妇300例,根据其是否感染生殖道B族链球菌(GBS)分为感染组(n=25)和正常组(n=275),观察并对比两组孕妇妊娠结局以及新生儿出生后情况之间的差异,并分析所有患者年龄、产次、流产及高危孕妇等因素对GBS感染率影响。结果:两组患者产后出血及晚期产后出血发生率比较差异无统计学意义(P>0.05);感染组胎膜早破、宫内感染、产褥感染、早产及剖宫产发生率显著高于正常组,差异均有统计学意义(P<0.05);感染组新生儿感染、新生儿窒息、胎儿生长受限、新生儿肺炎发生率显著高于正常组,差异均有统计学意义(P<0.05);所有患者年龄、产次、流产及高危孕妇等因素导致孕妇感染GBS率比较差异无统计学意义(P>0.05)。结论:孕晚期孕妇感染GBS后,会使孕晚期孕妇妊娠结局恶化,同时使分娩后的新生儿疾病发生率明显上升。

Objective:To investigate the effects of genital tract B streptococcal infection on pregnancy outcomes and neonates in pregnant women.Method:A total of 300 pregnant women who were pregnant for more than 35 weeks in the Department of Obstetrics and Gynecology in Longhua Hospital from July 2017 to July 2018 were enrolled.According to whether they were infected with genital tract B group streptococci(GBS),they were divided into infected group(n=25)and normal group(n=275).The pregnancy outcomes of the two groups pregnant women and the conditions after birth,the effect of GBS infection rate based on factors such as age,parity,abortion and high-risk pregnant women were observed and compared.Result:There were no significant differences in the incidence of postpartum hemorrhage and late postpartum hemorrhage between the two groups(P>0.05).The incidence of neonatal infection,neonatal asphyxia,fetal growth restriction and neonatal pneumonia in the infected group were significantly higher than those of the normal group,the differences were statistically significant(P<0.05).The incidence of neonatal infection,neonatal asphyxia,fetal growth restriction and neonatal pneumonia in the infected group were significantly higher than those of the normal group(P<0.05).There were no significant differences in the probability of infection with GBS among pregnant women,including age,parity,abortion and high-risk pregnant women(P>0.05).Conclusion:Infected with GBS in pregnant women in the third trimester,it will lead to the deterioration of pregnancy outcome in pregnant women in the third trimester,and the incidence of neonatal diseases after childbirth will increase significantly.