桃红四物汤联合复位外固定术对不稳定型桡骨远端骨折患者的临床疗效

Clinical effects of Taohong Siwu Decoction combined with reduction and external fixation surgery on unstable distal radial fractures patients

目的探讨桃红四物汤联合复位外固定术对不稳定型桡骨远端骨折患者的临床疗效。方法 75例患者随机分为对照组(35例)和观察组(40例),对照组给予复位外固定术,观察组在对照组基础上加用桃红四物汤,8周为1个疗程。然后,检测总有效率、骨折修复细胞因子[骨形态发生蛋白-2(BMP-2)、血管内皮生长因子(VEGF)、转化生长因子-β1(TGF-β1)]、钙磷代谢[钙(Ca)、磷(P)、碱性磷酸酶(ALP)]、骨密度、骨代谢指标[骨钙素、总Ⅰ型胶原氨基端延长肽(tPINP)、抗酒石酸酸性磷酸酶-5b(TRACP-5b)]、术后恢复、不良反应发生率变化。结果观察组总有效率显著高于对照组(P<0.05)。治疗后,2组骨折修复细胞因子、钙磷代谢显著升高(P<0.05),骨密度、骨代谢指标显著改善(P<0.05),以观察组更明显(P<0.05);观察组术后恢复显著更优(P<0.05);不良反应发生率显著降低(P<0.05)。结论桃红四物汤联合复位外固定术可促进不稳定型桡骨远端骨折患者骨折愈合,减少并发症,安全性较高。

AIM To explore the clinical effects of Taohong Siwu Decoction combined with reduction and external fixation surgery on unstable distal radial fractures patients.METHODS Seventy-five patients were randomly divided into control group(35 cases)and observation group(40 cases),the control group was given reduction and external fixation surgery,while the observation group was added with Taohong Siwu Decoction on the basis of the control group,8 weeks as a course of treatment.Subsequently,the changes in total effective rate,fracture repair cytokines[bone morphogenetic protein-2(BMP-2),vascular endothelial growth factor(VEGF),transforming growth factor-β1(TGF-β1)],calcium and phosphorus metabolisms[calcium(Ca),phosphorus(P),alkaline phosphatase(ALP)],bone density,bone metabolism indices[osteocalcin,total procollagen typeⅠamino-terminal propeptide(tPINP),tartrate-resistant acid phosphatase 5 b(TRACP 5 b)],postoperative recovery and occurrence rate of adverse reactions were detected.RESULTS Significantly higher total effective rate in the observation group than that in the control group was observed(P<0.05).After the treatment,the two groups demonstrated markedly increased fracture repair cytokines and calcium and phosphorus metabolisms(P<0.05),and obviously improved bone density and bone metabolism indices(P<0.05),especially for the observation group(P<0.05).And the observation group shared significantly better postoperative recovery(P<0.05),and markedly decreased occurrence rate of adverse reactions(P<0.05).CONCLUSION For the unstable distal radial fractures patients,Taohong Siwu Decoction combined with reduction and external fixation surgery can promote fracture healing and reduce complications,with high safety.