帕金森病和多系统萎缩患者嗅觉障碍比较的研究

A comparison of study of olfactory dysfunction in Parkinson’s disease patients and multiple system atrophy patients

了解帕金森病(PD)和多系统萎缩(MSA)患者嗅觉功能障碍的表现和特点,并对比两者之间的差异,拟探讨嗅觉检测试验对检测两种疾病嗅觉功能的价值及其鉴别诊断的临床意义。选择46例PD患者、23例MSA患者为研究对象,正常对照组40例;对其分别进行气味感知阈值和气味识别测定。PD组与MSA组及对照组气味感知阈值、气味识别试验比较差异均有统计学意义(P<0.01),PD组气味感知阈值和气味识别与病情严重程度及病程无相关性(P>0.05)。嗅觉障碍(OD)存在于大多数PD患者中,PD与MSA嗅觉比较有明显差异,嗅觉功能检测有助于PD与MSA的早期识别。

To comprehend the manifestation and characteristic of olfactory dysfunction in idiopathic Parkinson’s disease(PD)patients and multiple system atrophy(MSA)patients and to explore the differences of olfactory dysfunction between them.To explore the value of olfactory detection test in detecting the olfactory function and the clinical significance for differential diagnosis of PD and MSA.46 patients with PD and 23 patients with MSA were selected as experiment groups.40 healthy people were selected as control group.All the patients and the control group were detected the odor threshold test and odor identification test.There was significant difference between the groups of PD and the controls in the odor threshold test and odor identification test(P<0.01).There was significant difference between the groups of PD and MSA in the odor threshold test and odor identification test(P<0.01).There was no correlation between the results of odor threshold test and odor identification test and the duration of disease or the serious degree of the disease(P>0.05).Most of PD patients have olfactory dysfunction.There was significant difference between the groups of PD and MSA in olfaction.Olfactory function detection was helpful for early identification of PD and MSA.