自拟沙参麦冬鳞癌方治疗晚期肺鳞癌(气阴两虚型)60例临床疗效观察

Advanced Lung Squamous Cell Carcinoma Treated by Self-Made Shashen Maidong Lin'ai Formula: A Clinical Observation of 60 Cases of the Pattern of Qi-Deficiency and Yin-Deficiency

目的:观察沙参麦冬鳞癌方对晚期肺鳞癌患者(气阴两虚型)的临床治疗效果。方法:将晚期肺鳞癌患者(辨证属气阴两虚型)60例随机均分为两组,对照组予以对症治疗(呕吐者予以护胃止呕药物;粒细胞减少者予以升粒细胞药物;内环境紊乱者予纠正水电解质代谢、酸碱平衡等);治疗组在与对照组治疗方法相同的前提下,加用沙参麦冬鳞癌方。结果:(1)经治疗,两组各个临床观察指标(中医症候积分、近期客观疗效、KPS评分、血清CEA水平)变化情况均有统计学差异(P<0.05),对照组不及治疗组;(2)两组不良反应发生差异无统计学意义(P>0.05)。结论:沙参麦冬鳞癌方对治疗气阴两虚型的晚期肺鳞癌患者可取得较好疗效,无明显不良反应。

Objective: To observe the clinical effect of Shashen Maidong Lin'ai Formula on advanced lung squamous cell carcinoma of qi -deficiency and yin -deficiency. Methods: 60 patients with advanced lung squamous cell carcinoma of qi -deficiency and yin -deficiency were randomly divided into the control group and the treatment group. The control group was treated with general symptomatic treatment;on which basis, the treatment group was also treated with Shashen Maidong Lin'ai Formula. The treatment course was three months. Results: After the treatment, the treatment group was better than the control group in terms of improving TCM symptom scores, KPS scores, short-term objective effects, and serum level of CEA( P <0.05). There was no statistical difference in adverse reactions between the two groups( P >0.05). Conclusion: Shashen Maidong Lin'ai Formula can effectively treat advanced lung squamous cell carcinoma of the qi -deficiency and yin -deficiency, without obvious adverse reactions.