某市三甲医院医疗职业人群甲状腺功能调查分析

Investigation and analysis of thyroid function of medical occupational population in a tertiary-A hospital in Nanjing

目的评价长期接触低剂量电离辐射的医疗职业人群甲状腺激素水平的变化,分析各因素与甲状腺激素水平之间的关系,为制订电离辐射防护标准和开展职业人群辐射防护提供科学依据。方法选择2016年1至12月南京市某三甲医院参加职业健康检查的161名从事医疗放射诊治工作的医务人员为接触组;同时间段无职业性电离辐射接触的某企业行政人员159人为对照组。用自行设计的调查表进行问卷调查研究,从当地疾控部门采集接触组人群电离辐射的职业暴露剂量,检测人群的甲状腺相关激素水平,分析接害年限、工种、平均工龄、累计剂量对甲状腺激素的影响。结果接触组人群辐射接触的剂量均低于国家限定值的10%,属于低剂量暴露。与对照组比较,接触组人群T3、FT3水平低,差异均有统计学意义(P<0.05);能不同接害年限的接触组人群FT3水平差异有统计学意义(F=3.7,P<0.05)。结论长期接触低剂量电离辐射可引起医疗职业人群的甲状腺激素水平改变,应当予以关注。

Objective To evaluate the effect of low-dose of ionizing radiation on thyroid function of medical occupational group with long-term exposure,furthermore,to analyze the relationship between the thyroid hormones and the risk factors,such as exposure length,department and comulative radiation dose.Ultimately,providing the scientific basis for setting the ionizing radiation protection standards.Methods The population who engaged radiodiagnosis and radiotherapy in a tertiary-A hospital was set up as occupational exposure,and the administrative staffs in a company were considered as control.According to the inclusion and exclusion criteria,161 medical professionals and 159 administrative staffs as the research object.We figured out the basic information and general condition of the groups by face-to-face questionnaire survey,calculated the annual comulative radiation dose through local center for disease control and prevention,By means of the thyroid hormone testing,we analyzed the thyroid hormone levels with different population,occupational exposure factors.Applying Epidata、Excel in data management.All the data was analyzed by statistical software package Stata12.0.Descriptive statistics,single factor analysis of variance and other statistical methods were used for data analysis.Test standard:α=0.05、P<0.05 statistical significant.Results Age,sex and seniority were proportionality between exposure and control groups.The dosages of occupational population exposure to ionizing radiation were about 1/10 of national permit value,belonging to low-dose exposure.The T3,FT3 level of the exposure group was decreased than the control group(P<0.001).especially the FT3 level has statitical discrepancy among groups with different exposure length(P<0.05).Conclusion Long-term exposure to low-dose ionizing radiatiom can induce the thyroid damage of medical occupational population,which should be broader concerned.