卵低温保存过程中透明带提早硬化的影响因素和调控机制

Influencing factors and control mechanisms of premature zona hardening during oocyte cryopreservation

人卵低温保存是女性生育力保存和不育症治疗的重要辅助生殖技术,但其导致的透明带提早硬化使体外受精率显著降低,且其机制尚不明确。本文对透明带在卵低温保存过程中发生提早硬化的影响因素和调控机制进行了综述,有助于加强研究以提高卵低温保存技术和辅助生殖技术的有效性和安全性。

Oocyte cryopreservation is an important assisted reproductive technology for the preservation of female fertility and the treatments of various fertility problems, but the premature hardening of the zona pellucida induced during oocyte cryopreservation leads to a significant decrease in fertilization rate of the cryopreserved oocytes byin vitro fertilization (IVF). The mechanism of premature hardening of the zona pellucida is unclear. In this paper we systematically reviewed the influencing factors and the control of the premature zona hardening during oocyte cryopreservation for the purpose of strengthening research to improve the effectiveness and safety of oocyte cryopreservation and assisted reproductive technologies.