糖尿病性黄斑水肿的发病机制及治疗进展

Pathogenesis and Treatment of Diabetic Macular Edema

糖尿病性黄斑水肿( diabetic macular edema, DME)是导致糖尿病患者中心视力受损的重要原因之一, DME发病机制复杂, 主要是由于血 -视网膜屏障破坏, 血管通透性增加所致.血管内皮生长因子( vascular endothelial growth factor, VEGF)及各种炎症因子共同参与了 DME 的病理发展过程.激光光凝和抗VEGF治疗是目前治疗DME的有效方法, 玻璃体腔内注射糖皮质激素也被广泛应用.本文就DME的发病机制及治疗进展做一综述.

Diabetic macular edema ( DME) is an important cause of visual impairment in diabetic patients. DME is mainly caused by the disruption of blood - retinal barrier and the leakage of retinal vessels. Vascular endothelial growth factors ( VEGF) and other inflainrrnitory factors are involved in the pathogenesis of DME. Laser photocoagulation tind anti -\ EGF therapy are effective methods in the treatment of DME. Intravitreal injection of glucocorticoids is also widely used. This article reviews the pathogenesis and treatment of DME.