细菌对抗菌药物产生氧化应激的研究进展

Research progress in oxidative stress induced by antibiotics in bacteria

抗菌药物不仅可以通过与特定靶点相结合而发挥抗菌作用,也可通过诱导活性氧(reactive oxygen species,ROS)积累造成菌体氧化损伤。细菌对于氧化应激损伤,也有相应的防御机制,对ROS进行清除及损伤修复。然而细菌体内ROS的累积在抗菌药物杀菌过程中的作用机制却极其复杂。因此,本文对抗菌药物作用下细菌发生氧化应激的机制进行综述,并简要分析现有研究存在的问题及需要进一步解决的问题。

Antibiotics can not only combine with specific targets,but also induce a cascade of reactive oxygen species(ROS)in bacteria.Antioxidant defense system plays an important role in scavenging ROS and repairing injury against oxidative stress.However,the mechanism of ROS accumulation in bacteria and the action of ROS are very complicated.Therefore,this paper reviewed the mechanisms of bacterial responding to oxidative stress in the existence of antibiotics.In addition,we analyzed the main problems lying in the current study and the issues needing further consideration.