武汉地区儿童急性肠套叠病例的临床流行病学特征

Epidemiological characteristics of acute intussusception in children in Wuhan area

目的了解武汉地区儿童急性肠套叠临床流行病学特征。方法对2012-2017年武汉儿童医院收治的7 333例急性肠套叠患者的病例资料进行回顾性分析。结果男5 030例,女2 303例,男:女比例为2.2∶1;各年龄段男女比例从1.9∶1逐渐增加至2.7∶1。发病年龄为1个月至15岁,2岁以内占72.9%,8～9个月龄为高发年龄段;男童发病平均年龄高于女童;<12个月龄组病例数逐年减少,24～36及> 36个月龄组逐年增加,而12～24个月龄组无明显变化。4-8月份为高发时间。空气灌肠整复成功组及失败组在年龄、阵发性哭吵/腹痛、血便、腹部包块、呕吐、发热、腹泻及住院时间等方面的差异均有统计学意义。病程时间<24 h、24～48 h及> 48 h组间的整复结果及住院时间差异均有统计学意义。结论武汉地区儿童急性肠套叠在性别、年龄、发病季节、病程时间及临床表现各方面有一定的流行病学特征;整复成功组及失败组在各临床表现方面均有差异;病程时间与整复结果、住院时间间有一定的关系。

Objective To discuss the clinical epidemiological characteristics of acute intussusception in children in Wuhan area. Methods 7 333 cases of acute intussusception,who were admitted to Wuhan Children's Hospital from 2012 to 2017, were retrospectively analyzed. Results There were 5 030 males and 2303 females with a ratio of 2.2∶ 1, and it increased gradually from 1.9∶ 1 to 2.7∶1 in different age groups. The age of onset was from 1 month to 15 years old,among which 5 347 cases( 72.9%) were below 2 years old,and the peak age was from 8 to 9 months. The male average age was elder than that of the female. The case of intussusception below 12 months decreased year by year and increased yearly between 24 to 36 months and more,but it did not change significantly between 12 to 24 months. Peak incidence occurred from April to August. After air enema,there were significant differences between the success group and the failure group in clinical manifestations such as age,paroxysmal crying,abdominal pain,jam like bloody stool,abdominal mass,vomiting,fever,diarrhea and average inpatient days. The differences of clinical outcome and inpatient days were statistically significant between the three groups by courseofthedisease(<24hours,24~48hours and >48hours).Conclusions Epidemiologicalcharacteristics of acute intussusception in children in Wuhan area has its own features in terms of gender,age,course of disease, seasonal distribution and clinical manifestations. The differences of clinical manifestations between successful and failed group were statistically significant. Moreover,there were some relationships among inpatient days,disease duration and clinical outcomes.