实体器官移植受者移植术后下消化道并发症流行病学及影响因素

The epidemiology and influence factors of lower digestive tract diseases in solid organ transplantation recipients

实体器官移植(SOT)作为治疗终末期器官衰竭疾病的有效手段,临床开展越来越广泛。随着外科手术技术及术后管理水平的逐年提高及新型免疫抑制剂的应用,SOT受者术后生存率和生存质量不断提高。国外研究发现,SOT受者术后下消化道并发症(如憩室炎、结肠息肉和结直肠癌等)发生率随术后时间延长逐年增加,并成为影响受者生存时间和生存质量的重要因素。但目前国内这方面研究较少,且大多为个案报道。本文旨在对近年来SOT受者移植术后下消化道并发症流行病学及其影响因素相关研究进行综述,以期为临床预防及早期诊治提供依据,改善受者预后。

As the best choice for end- stage organ diseases, solid organ transplantation(SOT)has been applied more and more in clinical practice for years. With the improvement of surgical techniques, the application of new immunosuppressive agents and the improvement of postoperative management, the survival rate and quality of life of SOT recipients have been continuously improved. However, studies have found that the complications of lower digestive tract after SOT increased gradually with the time goes on, including diverticulitis, colon polyps and colorectal cancer, et al, which have influenced SOT recipients′ survival time and their quality of life significantly. There are few studies in this aspect published in China, and most of which are published as case reports. The aim of this article is to review the epidemiology and impact factors of lower digestive tract diseases among the SOT recipients, providing data support for clinical prevention and early intervention in order to improve the prognosis in these recipients ultimately.