持续内分泌治疗联合白蛋白结合型紫杉醇和泼尼松对中晚期前列腺癌的治疗效果

Effect of continuous endocrine therapy combined with albumin-bound paclitaxel and prednisone on advanced prostate carcinoma

目的探讨持续内分泌治疗联合白蛋白结合型紫杉醇和泼尼松对中晚期前列腺癌的治疗效果。方法将我院泌尿外科2015年8月至2017年11月收治的34例中晚期前列腺癌患者按随机数表法分为常规组(n=17,持续内分泌治疗)和联合组(n=17,持续内分泌治疗联合白蛋白结合型紫杉醇和泼尼松)。比较两组的治疗效果。结果联合组的治疗总有效率明显高于常规组(P<0.05)。治疗后,两组最大尿流率、NRS及EPIC评分均显著改善,且联合组均明显优于常规组(P<0.05);两组PSA、VEGF水平均显著降低,且联合组均明显低于常规组(P<0.05)。两组的骨髓抑制、消化系统症状、头晕乏力、皮肤症状发生率无显著差异(P>0.05)。联合组疾病进展率明显低于常规组(P<0.05)。结论持续内分泌治疗联合白蛋白结合型紫杉醇和泼尼松治疗中晚期前列腺癌效果显著,其可有效提升患者远近期疗效,缓解临床症状,改善生存质量。

Objective To investigate the effect of continuous endocrine therapy combined with albumin-bound paclitaxel and prednisone in the treatment of advanced prostate carcinoma.Methods From August 2015 to November 2017,34 patients with advanced prostate carcinoma were divided into routine group(n=17,continuous endocrine therapy)and combined group(n=17,continuous endocrine therapy combined with albumin-bound paclitaxel and prednisone)by random number table method.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the combined group was significantly higher than that of the routine group(P<0.05).After treatment,the maximum urinary flow rate and scores of NRS and EPIC in both groups significantly improved,and those in the combined group were significantly better than the routine group(P<0.05);the levels of PSA and VEGF in both groups significantly decreased,and those in the combined group were significantly lower than the routine group(P<0.05).There were no significant differences in the incidences of arrest of bone marrow,digestive system symptoms,dizziness and fatigue,skin symptoms between the two groups(P>0.05).The disease progression rate in the combined group was significantly lower than that in the routine group(P<0.05).Conclusion Continuous endocrine therapy combined with albumin-bound paclitaxel and prednisone is effective in the treatment of advanced prostate carcinoma,which can effectively improve the long-term and short-term efficacy of patients,alleviate clinical symptoms and improve the quality of life.