盐酸氨溴索雾化吸入联合无创正压通气治疗COPD急性加重期的临床效果

Clinical effect of ambroxol hydrochloride atomization inhalation combined with noninvasive positive pressure ventilation on acute exacerbation of COPD

目的探讨盐酸氨溴索雾化吸入联合无创正压通气治疗慢性阻塞性肺病(COPD)急性加重期患者的临床效果。方法将90例COPD急性加重期患者随机分为对照组和观察组,各45例。对照组采用无创正压通气治疗,观察组在对照组基础上联合盐酸氨溴索雾化吸入治疗。比较两组的治疗效果。结果治疗后,两组PaO_2、SaO_2水平均升高,且观察组明显高于对照组(P<0.05)。观察组咳嗽、喘息、肺部啰音缓解时间均明显短于对照组(P<0.05)。观察组的治疗总有效率明显高于对照组(P<0.05)。结论盐酸氨溴索雾化吸入联合无创正压通气治疗COPD急性加重期效果显著,其可改善患者血气分析指标,促进其临床症状好转,值得临床推广应用。

Objective To investigate the clinical effect of ambroxol hydrochloride atomization inhalation combined with noninvasive positive pressure ventilation on acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods Ninety patients with acute exacerbation of COPD were randomly divided into control group and observation group,with 45 cases in each group.The control group was treated with noninvasive positive pressure ventilation,while the observation group was treated with ambroxol hydrochloride atomization inhalation on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the levels of PaO2 and SaO2 increased in both groups,and those in the observation group were significantly higher than the control group(P<0.05).The relief time of cough,wheezing and lung rale in the observation group were significantly shorter than those in the control group(P<0.05).The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).Conclusion Ambroxol hydrochloride atomization inhalation combined with noninvasive positive pressure ventilation in the treatment of acute exacerbation of COPD has a significant effect.It can improve the blood gas analysis indexes of patients and promote the improvement of their clinical symptoms,and is worthy of clinical promotion and application.