医用透明质酸钠在玻璃体腔注药术前消毒中对角膜的保护效果

Protective effect of medical sodium hyaluronate on cornea in disinfection before vitreous cavity injection

目的研究玻璃体腔注药术前消毒中应用医用透明质酸钠对角膜的保护效果。方法选取在我院行玻璃体腔注药的150例患者为研究对象,采用随机数字表法将患者分为观察组和对照组,各75例。对照组术前采用5%聚维酮碘滴入结膜囊内消毒,观察组消毒前将医用透明质酸钠均匀涂抹于角膜表面。观察比较两组患者结膜充血及角膜损伤情况、干眼症状评分(DESS)及泪膜破裂时间(BUT)。结果两组患者无眼内炎发生,对照组发生角膜上皮部分剥脱2例。观察组患者结膜充血分级优于对照组,差异具有统计学意义(P<0.05);手术前,两组患者的DESS评分、BUT比较,差异无统计学意义(P>0.05);手术后,两组患者的DESS评分均升高,BUT均缩短,且观察组显著优于对照组,差异具有统计学意义(P<0.05)。结论医用透明质酸钠可在玻璃体腔注药术前聚维酮碘消毒结膜囊时起到保护角膜的作用,值得临床推广使用。

Objective To investigate the protective effect of medical sodium hyaluronate on cornea in disinfection before vitreous cavity injection.Methods A total of 150 patients with vitreous cavity injection in our hospital were selected.All patients were divided into control group and observation group by random number table method,with 75 cases in each group.The control group was given 5%povidone-iodine drop into conjunctival sac for disinfection.The observation group was given sodium hyaluronate at the corneal surface before disinfection.The conjunctival hyperemia and corneal damage,dry eye symptom scores(DESS)and tear break-up time(BUT)in the two groups were observed and compared.Results There was no endophthalmitis occurred in both groups,and 2 cases of patients in the control group occurred corneal epithelial partial exfoliation.The conjunctival hyperemia grade in the observation group was better than that in the control group,and the difference was statistically significant(P<0.05).Before surgery,there were no significant differences in DESS scores and BUT between the two groups(P>0.05).After surgery,the DESS scores in both groups increased,the BUT shortened,and those in the observation group were better than the control group,the differences were statistically significant(P<0.05).Conclusion Medical sodium hyaluronate in disinfection of povidone-iodine in conjunctival sac before vitreous cavity injection can play the role in protecting cornea,which is worthy of clinical promotion and application.