1例婴儿先心病术后并发CRE感染的病例分析

Analysis of a case of pediatric congenital heart disease complicated with postoperative CRE infection

细菌耐药是对全球健康和安全最严重的威胁之一。尤其是碳青霉烯耐药肠杆科细菌(CRE)导致的严重感染给临床治疗带来了极大的挑战,儿童CRE感染的治疗由于药物选择的限制更是难上加难。本文就临床药师对1例婴儿先心病术后并发CRE肺部感染、皮肤软组织感染和血流感染的病例进行分析,以期为临床治疗提供更多参考。本例患儿采用替加环素联合碳青霉烯类抗菌药物进行治疗,取得了较好的疗效。本文重点讨论了儿童CRE治疗如何选择抗菌药物。

Bacterial resistance is one of the most serious threats to global health and safety. In particular, severe infection caused by carbapenem-resistant Enterobacteriaceae (CRE) poses a great challenge to clinical treatment. The treatment of CRE infection in children is even more difficult due to the limitations of drug selection. The case of an infant with congenital heart disease complicated with CRE infection in lung, skin soft tissue and bloodstream was analyzed by clinical pharmacists so as to provide more references for clinical treatment. In this case, the infant was treated with tigecycline combined with carbapenems and good efficacy was obtained. The discussion was focused on how to select antibacterial agents for children with CRE infection.