芪苈强心胶囊治疗慢性心力衰竭作用机制研究进展

Research progress on the effect and mechanism of Qili Qiangxin Capsule in treating chronic heart failure

慢性心力衰竭(慢性心衰)是心血管事件链中的关键环节,以中医脉络学说为指导研发的创新中药芪苈强心胶囊对慢性心衰具有良好疗效,研究表明该药能够增强心肌收缩力,利尿,抑制神经内分泌系统过度激活,抑制炎症反应、心肌纤维化、细胞凋亡和自噬,改善心肌能量代谢,促进血管新生,改善内皮功能,从而抑制心室重构,延缓慢性心衰进程。探讨芪苈强心胶囊治疗慢性心衰的作用及机制,有利于从多靶点、多通道发挥该药治疗作用,同时为心血管事件链中其他难治性疾病提供更广阔的治疗思路,对提高中医药治疗心血管疾病具有重大的理论与临床意义。

Chronic heart failure is a key part of cardiovascular continuum. Under the guidance of the theory of vessel-collateral doctrine, the present study proposes therapeutic benefits of Qili Qiangxin Capsules,an innovative Chinese medicine,on chronic heart failure. The studies show that multiple targets of the drug on chronic heart failure,including enhancing myocardial systole,promoting urine excretion, inhibiting excessive activation of the neuroendocrine system,preventing ventricular remodeling by inhibiting inflammatory response, myocardial fibrosis,apoptosis and autophagy,enhancing myocardial energy metabolism,promoting angiogenesis and improving endothelial function. To investigate the effect and mechanism of the drug is beneficial to the treatment of chronic heart failure through multiple targets or signaling pathways. Meanwhile,it provides new insights to further understand other refractory diseases in the cardiovascular continuum,and it also has an important theoretical and practical significance in enhancing prevention and therapeutic effect of traditional Chinese medicine for these diseases.