肝癌患者TACE术治疗前后血清VEGF、bFGF、HIF-1α水平变化及其临床意义

Changes of Serum VEGF,bFGF and HIF-1α Levels in Patients with Liver Cancer Before and After TACE and Their Clinical Significances

目的探讨肝癌患者肝动脉化疗栓塞术(TACE)治疗前后血清血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)、缺氧诱导因子-1α(HIF-1α)变化及临床意义。方法选取2014年1月至2017年1月医院行TACE治疗的肝癌患者86例作为研究对象,检测术前3d及术后1、7、28d血清VEGF、bFGF、HIF-1α水平,并分析其与TACE疗效、术后复发的关系。结果与术前比较,TACE术后1、7 d VEGF、bFGF、HIF-1α水平升高,术后28 d上述指标均降低,差异有统计学意义(P <0. 05)。86例患者中,治疗有效率为32.56%(28/86),以CR+PR作为有效组,以SD+PD作为无效组,有效组术后1、7、28 d VEGF、bFGF、HIF-1α水平低于无效组,差异有统计学意义(P<0.05);86例患者中,术后6个月复发率为18.60%(16/86),以术后6个月复发患者作为复发组,以未复发患者作为未复发组,复发组术后1、7、28 d VEGF、bFGF、HIF-1α水平高于未复发组,差异有统计学意义(P <0.05)。结论肝癌患者TACE术后VEGF、bFGF、HIF-1α变化可能与手术效果、术后复发情况有关。

Objective To investigate changes of serum vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF)and hypoxia inducible factor -1 α(HIF-1 α)in patients with liver cancer before and after transcatheter arterial chemoembolization(TACE)and their clinical significances.Methods 86 patients with liver cancer who underwent TACE in the hospital from January,2014 to January,2017 were selected as the study subjects.Serum VEGF,bFGF and HIF-1 α levels were detected at 3 days before surgery and 1 day,7 days and 28 days after the operation.Their relationships with the curative effect of TACE and postoperative recurrence were analyzed.Results The levels of VEGF,bFGF and HIF-1 α increased at 1 day and 7 days after TACE,and decreased at 28 days after TACE(P <0.05).Among 86 patients,the effective rate of treatment was 32.56%(28/86).CR + PR was taken as the effective group,while SD + PD was taken as the ineffective group.Levels of VEGF,bFGF and HIF-1 α in the effective group at 1 day,7 days and 28 days after the operation were lower than those in the ineffective group(P <0.05).Meanwhile,the recurrence rate in the same cohort was 18.60%(16/86)6 months after the operation.Patients with recurrence in 6 months after the operation were included in the recurrence group,while those without were included in the non-recurrence group.The levels of VEGF,bFGF and HIF-1 α in the recurrence group at 1 day,7 days and 28 days after the operation were higher than those in the non-recurrence group(P <0.05).Conclusion The changes of VEGF,bFGF and HIF-1 α in patients with liver cancer after TACE could be related to the operative effects and postoperative recurrence.