肺康复对非小细胞肺癌行肺切除术患者术后免疫功能和生活质量的影响

Effect of Pulmonary Rehabilitation on Postoperative Immune Function and Quality of Life in Patients with Non-small Cell Lung Cancer Undergoing Pneumonectomy

目的观察肺康复对非小细胞肺癌(NSCLC)行肺切除术患者术后免疫功能和生活质量的影响。方法选取我院2017年4月～2018年8月收治的72例NSCLC并接受肺切除术患者,随机分为观察组和对照组,各36例。两组患者都遵医嘱给予常规药物治疗,观察组在此基础上给予肺康复干预。记录患者术后住院期间的并发症发生情况和肋间导管置留时间,分别在术前1 d、术后4周记录患者改良版伯格呼吸困难量表(MBS)评分、免疫功能指标(CD3、CD4、CD8)和生活质量评分。结果观察组并发症发生情况(27.73%vs 52.74%)和肋间导管置流的时间[(5.48±0.87)d vs (7.34±0.92)d]均少于对照组,差异有统计学意义(P<0.05);术后4周,两组患者免疫功能、生活质量评分和MBS评分较治疗前改善,差异有统计学意义(P<0.05);且治疗组免疫功能、生活质量评分和MBS评分改善情况优于对照组,差异有统计学意义(P<0.05)。结论 NSCLC行肺切除术患者术后肺康复干预可以降低术后肺部并发症的发生率,减短患者术后肋间导管置留时间,改善其免疫功能和生活质量。

Objective To observe the effect of pulmonary rehabilitation on postoperative immune function and quality of life in patients with non-small cell lung cancer(NSCLC)undergoing pneumonectomy.Methods 72 patients with NSCLC admitted to our hospital from April 2017 to August 2018 were enrolled in the observation group and the control group,36 cases each.Both groups of patients were given conventional medication according to the doctor's advice,and the observation group was given pulmonary rehabilitation intervention.The complication of postoperative hospitalization and intercostal catheter retention time were recorded.The modified Berger's dyspnea scale(MBS)score and immune function index(CD3,CD4,CD8)were recorded 1 dbefore surgery and 4 weeks after surgery,and quality of life scores.Results The complication of the observation group(27.73%vs 52.74%)and the time of intercostal catheter placement[(5.48±0.87)d vs(7.34±0.92)d]were lower than the control group,the difference was statistically significant(P<0.05);4 weeks after operation,the immune function,quality of life score and MBS score of the two groups were improved compared with those before treatment(P<0.05);and the immune function,quality of life score and MBS score of the treatment group improved.The situation was better than the control group,the difference was statistically significant(P<0.05).Conclusion Postoperative pulmonary rehabilitation intervention in patients with NSCLC pneumonectomy can reduce the incidence of postoperative pulmonary complications,reduce the postoperative intercostal catheter retention time,and improve their immune function and quality of life.