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康复新液辅助生长抑素治疗非甾体药物致上消化道出血临床疗效研究 被引量:5

Study on the Clinical Effect of Kangfuxin Liquid Assisted Somatostatin in the Treatment of Upper Gastrointestinal Hemorrhage Caused by Non-steroidal Drugs
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摘要 目的分析非甾体药物所致上消化道出血(UGH)患者应用康复新液辅助生长抑素治疗的疗效。方法选择2016年6月~2018年6月入本院实施治疗的UGH患者88例进行分组研究,分组方式为随机双盲法,每组44例。两组患者均采取常规基础治疗加生长抑素治疗,观察组还加用康复新液辅助治疗。评价两组临床疗效,记录止血时间与再出血率,测定治疗前后血清炎性因子,并比较。结果观察组临床总有效率高于对照组(P <0.05);观察组止血时间更短,组间差异有统计学意义(P <0.05),但两组再出血率比较无显著差异(P> 0.05);两组治疗前血清肿瘤因子-α(TNF-α)、白介素-6(IL-6)比较无显著差异(P> 0.05),治疗后观察组均低于对照组(P <0.05)。结论非甾体药物所致UGH在生长抑素治疗基础上加用康复新液辅助治疗,一方面可提高临床疗效,缩短止血时间,另一方面可以改善血清炎性因子,且再出血率略低,值得临床应用。 Objective To analyze the therapeutic effect of kangfuxin fluid assisted somatostatin on upper gastrointestinal hemorrhage (UGH) caused by non-steroidal drugs. Methods 88 cases of UGH patients admitted to our hospital for treatment from June 2016 to June 2018 were selected for grouping study. The grouping method was randomized double-blind method, with 44 cases in each group. Patients in both groups were treated with conventional basic therapy plus somatostatin, and patients in the observation group were added with kangfuxin fluid. Clinical efficacy of the two groups was evaluated, hemostasis time and re-bleeding rate were recorded, serum inflammatory factors were measured and compared before and after treatment. Results The clinical total effective rate of the observation group was higher than that of the control group (P < 0.05). Hemostasis time was shorter in the observation group, and the difference between the two groups was statistically significant (P < 0.05), but there was no significant difference in the rate of re-bleeding between the two groups (P > 0.05). There was no significant difference in serum tumor factor-α(TNF-α) and interleukin-6 (IL-6) between the two groups before treatment (P > 0.05). After treatment, the levels of TNF-α and IL-6 in observation group were lower than the that in control group (P < 0.05). Conclusion kangfuxin fluid assisted somatostatin treated in upper gastrointestinal hemorrhage (UGH) caused by non-steroidal drugs can not only improve the clinical effect and shorten the hemostasis time, but improve the serum inflammatory factors, and slightly lower the re-bleeding rate, so it is worthy of clinical application.
作者 刘智慧 LIU Zhi-hui(Jiaozuo second people's hospital (the first affiliated hospital of Henan university of technology), second district ofgastroenterology, Jiaozuo, Henan, 454001, China)
出处 《临床研究》 2019年第5期127-128,共2页 Clinical Research
关键词 非甾体药物 上消化道出血 康复新液 生长抑素 辅助治疗 non-steroidal drugs upper gastrointestinal bleeding kangfuxin fluid somatostatin adjuvant therapy
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