银屑病与PRINS lncRNA相关性研究进展

The research progress of correlation between psoriasis and PRINS lncRNA

银屑病是一种常见免疫介导的,与遗传、代谢等多种因素相关的疾病,目前病因尚未清晰。近年来越来越多的研究表明,PRINS lncRNA作为一种新型长链非编码RNA在银屑病无损伤的表皮中呈高反应性,参与了G1P3之间的信号传递以及NPM蛋白的调控,其可调节炎症介质产生,在慢性炎症中发挥重要作用。本文就银屑病发病机制与PRINS lncRNA相关性的研究进展作一综述。

Psoriasis is a common immune-mediated disease associated with genetic, metabolic and other factors, and its cause is not clear yet. In recent years, there is a growing number of studies shown that PRINS lncRNA, as a new type of long chain non-coding RNA, has high reactivity in psoriasis skin without damage. What’s more, it participates in the signal transmission of G1P3 and the regulation of NPM protein, which can adjust inflammatory mediators and plays an important role in chronic inflammation. This review mainly discusses PRINS lncRNA and its functions in the pathogenesis of psoriasis and its research progress.