补肾活血中药治疗多囊卵巢综合征导致不孕症的Meta分析

Bushen Huoxue herbal medicine in subfertile women with polycystic ovary syndrome: a Meta-analysis

系统评价补肾活血中药与克罗米芬比较治疗多囊卵巢综合征导致不孕症的安全性和有效性,为临床用药提供循证依据。计算机检索CNKI,Wan Fang,VIP,Sino Med,PubMed,EMbase,the Cochrane Library 7个数据库,检索时间设为建库—2018年9月;根据纳入标准和排除标准筛选文章,提取资料,采用"偏移风险评估工具"进行质量评价,运用Review Manager 5. 3软件对结局进行Meta分析。最终纳入7项研究,共计634例患者。Meta分析结果显示补肾活血中药与克罗米芬相比,在提高妊娠率方面有一定优势,同时还可以降低LH,T,INS,但在提高排卵率和改善FSH方面无统计学意义。纳入的文献均未报告补肾活血中药的不良反应。补肾活血中药治疗多囊卵巢综合征导致不孕症临床疗效较好,安全性较高,但由于纳入文献研究质量相对偏低,结果可能存在偏倚,还需要更多高质量的临床研究加以验证。

Meta-analysis of randomized controlled trials( RCTs) was conducted to clarify the effect of Bushen Huoxue herbal medicine in subfertile women with polycystic ovary syndrome. Databases including CNKI,Wan Fang,VIP,Sino Med,PubMed,EMbase,the Cochrane Library were searched until September,2018. Two reviewers independently assessed study eligibility,extracted data,and evaluated the risk of bias for included trials. Meta-analysis used Review Manager 5.3 software. Seven RCTs( n = 634) were included.Results of Meta-analysis indicated that,Bushen Huoxue herbal medicine had advantages on increasing pregnancy rate,lowering LH,T and INS. Bushen Huoxue herbal medicine were not clear on increasing ovulation rate,increasing FSH. No serious adverse reaction appearing from Bushen Huoxue herbal medicine was reported in the including researches. The current Meta-analysis showed a promising effect of Bushen Huoxue herbal medicine in subfertile women with polycystic ovary syndrome,but the quality of current evidence was low and possible publication bias.