补肾活血中药治疗女性高催乳素血症随机对照试验的Meta分析

Bushen Huoxue herbal medicine for treating hyperprolactinemia in women: a Meta-analysis

系统评价补肾活血中药治疗高催乳素血症的安全性和有效性,为补肾活血中药治疗高催乳素血症提供循证医学证据。计算机全面检索PubMed,EMbase,Cochrane Library,CNKI,Wan Fang,VIP,CBM中关于补肾活血中药治疗高催乳素血症的随机对照试验并进行Meta分析。检索时间均为建库至2018年9月28日。根据纳入和排除标准遴选文章,提取数据,采用"偏移风险评估工具"进行质量评价,运用Review Manager 5. 3软件进行Meta分析。最终纳入13篇研究文献,合计816例高催乳素血症患者。Meta分析结果显示补肾活血中药与溴隐亭相比,在降低催乳素、提高妊娠率方面无统计学意义;在改善中医证候、降低疾病复发和减少副作用等方面补肾活血中药有明显优势。补肾活血中药治疗高催乳素血症临床疗效确切、安全可靠、远期复发率低,但因受到纳入文献质量限制,上述结论还需要更多大样本高质量的临床研究加以验证。

The clinical efficacy of Bushen Huoxue traditional Chinese medicine( TCM) in the treatment of hyperprolactinemia were systematically evaluated,which provided evidence-based medical evidence for the treatment of hyperprolactinemia with Bushen Huoxue traditional Chinese medicine. The randomized controlled trials on the treatment of hyperprolactinemia with Bushen Huoxue traditional Chinese medicine were comprehensively searched by computer in PubMed,EMbase,Cochrane Library,CNKI,Wan Fang,VIP,CBM and Meta-analysis was performed. The search time is from the time of self-built database to September 28,2018. A total of 816 patients with hyperprolactinemia met the inclusion criteria in 13 clinical studies. The results of Meta-analysis showed that compared with Western medicines,traditional Chinese medicine for tonifying kidney and activating blood circulation had a comparable effect in reducing prolactin and treating infertility,and had obvious advantages in improving of TCM syndromes,disease recurrence and reducing of side effects.