金纳米棒在肿瘤诊疗领域的表面修饰策略概述

Overview of surface modification strategies for gold nanorods in the field of tumor diagnosis and treatment

在贵金属纳米材料中,金纳米材料因其独特的光学、电子学和磁学性能被广泛应用于荧光、催化、生物医药、分子和细胞成像、癌症诊断与治疗等领域。包括金纳米颗粒(AuNPs)、金纳米壳(AuSs)、纳米滴和金纳米棒(AuNRs)在内的金纳米材料为癌症的诊疗提供了一个很有前途的平台。其中,金纳米棒具有可调的局部表面等离子共振,不仅可以作为癌细胞成像的探针,而且在受到激光辐照时产生光热效应还可以成为高强度的局部热源,生成的热量除了可用于癌症治疗外,还可以用于触发金纳米棒表面载带药物的释放。

Among precious metal nanomaterials, gold nanomaterials are widely used in fluorescence, catalysis, biomedicine, molecular and cellular imaging, cancer diagnosis and treatment due to their unique optical, electronic and magnetic properties. Gold nanomaterials including gold nanoparticles(AuNPs), gold nanoshells(AuSs), nanodroplets and gold nanorods(AuNRs)provide a promising platform for the diagnosis and treatment of cancer. Among them, the gold nanorods have adjustable local surface plasmon resonance, which can be used not only as a probe for imaging of cancer cells, but also can generate a high-intensity local heat source when subjected to laser irradiation, and the generated heat can be used in addition to In addition to cancer treatment, it can also be used to trigger the release of drugs on the surface of gold nanorods.