血清脂蛋白和红细胞刚性指数预测颈动脉狭窄患者脑梗死的价值

The value of serum lipoprotein and erythrocyte rigidity index in predicting cerebral infarction in patients with carotid artery stenosis The Values of Serum Lipoprotein and Red Cell Rigidity Index in Predicting Cerebral Infarction in Patients with Carotid

目的探讨血清脂蛋白和红细胞刚性指数预测颈动脉狭窄患者脑梗死的价值。方法将2016年2月至2018年1月确诊为颈动脉狭窄的121例患者,依据是否出现脑梗死分为非梗死组(63例)和梗死组(58例)。采用免疫透射比浊法检测患者血清脂蛋白水平,采用血流变仪检测红细胞刚性指数,ROC曲线分析血清脂蛋白和红细胞刚性指数对患者脑梗死的预测价值。结果梗死组血清脂蛋白和红细胞刚性指数均显著高于非梗死组(P<0.05);血清脂蛋白与红细胞刚性指数呈显著线性正相关关系(r=0.762,P=0.000);血清脂蛋白预测脑梗死的ROC曲线下面积(AUC)为0.710,敏感性为82.54%,特异性为53.45%;红细胞刚性指数预测脑梗死的ROC曲线下面积(AUC)为0.722,敏感性为73.02%,特异性为60.34%;高脂蛋白和红细胞刚性指数是诱发颈动脉狭窄患者脑梗死的危险因素。结论血清脂蛋白和红细胞刚性指数在颈动脉狭窄脑梗死和非脑梗死患者之间存在显著差异,可作为早期预测颈动脉狭窄患者脑梗死的检测指标。

Objective To explore the value of serum lipoprotein and erythrocyte rigidity index (ERI) in predicting cerebral infarction (CI) in patients with carotid artery stenosis (CAS). Methods A total of 121 patients with CAS who were definitely diagnosed in our hospital between February 2016 and January 2018 were divided into non-CI group ( n =63) and CI group ( n =58) according to presence or absence of CI. Serum lipoprotein levels were measured by immunoturbidimetric assay. ERI was measured by hemorheology. The ROC curve was used to analyze the predictive value of serum lipoprotein and ERI in CI of CAS patients. Results The rigidity indexes of serum lipoprotein and ERI of the CI group were significantly higher than those in non-CI group ( P <0.05). There was a significant positive linear correlation in rigidity indexes between serum lipoprotein and ERI ( r =0.762, P <0.01). The area under the ROC curve (AUC) of serum lipoprotein in predicting CI was 0.710, and sensitivity and specificity were 82.54% and 53.45%, respectively. The AUC of ERI in predicting CI was 0.722, and sensitivity and specificity were 73.02% and 60.34%,respectivevly. High lipoprotein and ERI were risk factors for CI in patients with CAS. Conclusion There are significant differences in rigidity indexes of serum lipoprotein and ERI between CI patients and non-CI patients due to CAS, which can be used as an early predictor of CI in patients with CAS.