中性粒细胞外诱捕网在肿瘤形成过程中的作用机制研究

The role of neutrophil extracellular traps in the tumor progression

中性粒细胞诱外捕网(neutrophil extracellular traps, NETs)是一种来源于中性粒细胞的DNA网状结构,能够捕获和杀死病原微生物,从而在宿主防御中发挥重要作用.越来越多的证据表明NETs与肿瘤的进展密切相关,且能够通过多种方式促进肿瘤的复发转移.其临床意义也逐渐突显出来.本综述重点阐述促癌微环境中NETs的形成及促进肿瘤复发转移的机制,并对NETs临床应用价值进行探究.

Neutrophil extracellular traps (NETs) are neutrophil-derived DNA structures. They have been shown to trap and kill microorganisms, playing a critical role in host defense. Increasing evidence has shown that NETs have a close relationship with tumor progression. And their contribution to tumor recurrence and metastasis has been demonstrated in a number of studies.Furthermore, the clinical significance of NETs has also been highlighted. In this review, emphasis was laid on the mechanism of the formation of NETs and their role in tumor progression in a cancer promoting microenvironment. In addition, the clinical value of NETs was also explored.