泮托拉唑联合加贝酯治疗急性胰腺炎的临床研究

Clinical study on pantoprazole combined with gabexate in treatment of acute pancreatitis

目的考察注射用泮托拉唑钠联合注射用甲磺酸加贝酯治疗急性胰腺炎的临床疗效。方法选取2016年2月—2017年3月在三二〇一医院就诊的急性胰腺炎患者68例作为研究对象,将所有患者随机分为对照组和治疗组,每组各34例。对照组患者静脉滴注注射用甲磺酸加贝酯,200 mg/d,1次/d。治疗组患者在对照组治疗的基础上静脉滴注注射用泮托拉唑钠,40mg/d,1次/d。两组患者均持续治疗7d。观察两组患者的临床疗效,同时比较两组患者治疗前后的生化指标和血清炎症因子水平。结果治疗后,治疗组总有效率为94.12%,显著高于对照组的79.41%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者的血淀粉酶(AMY)、尿淀粉酶(UAMY)和血尿素氮(BUN)水平均显著降低(P<0.05);治疗后治疗组的生化指标水平显著低于对照组(P<0.05)。治疗后,两组患者的血清白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平均显著降低(P<0.05);治疗后治疗组炎症因子水平明显低于对照组(P<0.05)。结论注射用泮托拉唑钠联合注射用甲磺酸加贝酯治疗急性胰腺炎具有较好的临床疗效,可改善患者的生化指标和炎症因子水平,且安全性高,具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Pantoprazole Sodium for injection combined with Gabexate Mesylate for injection in treatment of acute pancreatitis. Methods Patients(68 cases) with acute pancreatitis in San Er Ling Yi Hospital from February 2016 to March 2017 were randomly divided into control and treatment groups, and each group had 34 cases. Patients in the control group were iv administered with Gabexate Mesylate for injection 200 mg/d, once daily. Patients in the treatment group were iv administered with Pantoprazole Sodium for injection on the basis of the control group, 40 mg/d, once daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the biochemical index and inflammatory factor levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the treatment group was 94.12%, which was significantly higher than 79.41% in the control group, and there were differences between two groups(P < 0.05).After treatment, the levels of AMY, UAMY, and BUN in two groups were significantly decreased(P < 0.05). After treatment, the biochemical index levels in the treatment group were lower than those in the control group(P < 0.05). After treatment, the levels of IL-6 and TNF-α in two groups were significantly decreased(P < 0.05). After treatment, the inflammatory factor levels in the treatment group were lower than those in the control group(P < 0.05). Conclusion Pantoprazole Sodium for injection combined with Gabexate Mesylate for injection has good clinical efficacy in treatment of acute pancreatitis, can significantly improve the biochemical index and inflammatory factor levels with high safety, which has a certain clinical application value.