下肢动脉硬化闭塞伴足部溃疡病人溃疡愈合的最佳氧分压预测阈值探讨

Probeinto of optimum oxygen partial pressure prediction threshold of ulcer healing in patients with lower extremities atherosclerosis disease with foot ulcers

[目的]探讨下肢动脉硬化闭塞伴足部溃疡病人溃疡愈合最佳氧分压预测阈值。[方法]对25例下肢动脉硬化闭塞伴足部溃疡病人随访3个月后,利用经皮氧分压仪测量病人足背氧分压值,并根据病人溃疡愈合情况将病人分为溃疡愈合组(A组)、溃疡好转组(B组)及溃疡未愈合组(C组),通过ROC曲线分析溃疡愈合的最佳预测值。[结果]3个月后,12例病人溃疡愈合,5例有好转,8例病人未愈合。3组病人足背氧分压值不同(F=15.556,P=0.000)。ROC曲线得出最佳诊断界值为22mmHg。[结论]足背氧分压高于28mmHg,有利于溃疡的愈合;而小于10mmHg则溃疡不能愈合。预测阈值为22mmHg是预测溃疡愈合的最佳阈值。

Objective: To explore the optimum threshold of oxygen partial pressure for ulcer healing in patients with lower extremities atherosclerosis disease,LEAD;and foot ulcer. Methods: A total of 25 cases of LEAD patients with foot ulcer were followed up for 3 months,then using percutaneous oxygen partial pressure meter to measure oxygen partial pressure value.And according to ulcer healing, patients were divided into ulcer healing group(group A),improved ulcer group(group B) and unhealed ulcer group(group C).The optimal predictive value of ulcer healing was analyzed by ROC curve. Results: After 3 months,12 patients had healed,5 cases had improved and 8 cases had not healed.Patients in the three groups had different PDPPH values( F=15.556,P =0.000).The optimal diagnostic boundary value of ROC curve was 22 mmHg. Conclusions: Oxygen partial pressure at dorsal foot was higher than 28 mmHg,which was beneficial to the healing of ulcers.Ulcers can′t heal at less than 10 mmHg did not heal.The prediction threshold of 22 mmHg was the best one to predict ulcer healing.