子痫前期患者血清APN、TNF-α、Apelin水平的表达及相关性研究

Expression and Correlation of Serum APN, TNF-α and Apelin Levels in Patients with Preeclampsia

目的:探讨子痫前期患者血清脂联素(APN)、肿瘤坏死因子-α(TNF-α)、Apelin水平的表达及相关性。方法:选取2015年10月到2017年8月在辽河油田总医院妇产科就诊的子痫前期患者86例,根据患者的病情严重程度将其分为轻度子痫前期组(46例)和重度子痫前期组(40例),另选取同期在我院进行产检的健康孕妇40例作为对照组,比较三组受试者血清中APN、TNF-α、Apelin、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和总胆固醇(TC)水平,并分析子痫前期患者血清中APN、TNF-α、Apelin、LDL-C、TG、HDL-C、TC的相关性。结果:重度子痫前期组血清中APN水平低于轻度子痫前期组和对照组,TNF-α、Apelin水平高于轻度子痫前期组和对照组(P<0.05);轻度子痫前期组血清中APN水平低于对照组,TNF-α、Apelin水平高于对照组(P<0.05)。重度子痫前期组血清中LDL-C、TG、TC水平高于轻度子痫前期组和对照组,HDL-C水平低于轻度子痫前期组和对照组(P<0.05);轻度子痫前期组LDL-C、TC水平高于对照组,HDL-C水平低于对照组(P<0.05)。Pearson相关性分析结果显示,子痫前期患者血清中APN与TNF-α、Apelin、LDL-C、TG呈负相关,与HDL-C呈正相关(P<0.05);TNF-α与Apelin、LDL-C、TG、TC呈正相关,与HDL-C呈负相关(P<0.05);Apelin与LDL-C、TG、TC呈正相关,与HDL-C呈负相关(P<0.05)。结论:子痫前期患者血清中APN水平明显下降,TNF-α、Apelin明显升高,三种指标可相互影响,且均可影响机体的脂质代谢水平,共同调节子痫前期患者的疾病进展。

Objective: To investigate the expression and correlation of serum adiponectin(APN), tumor necrosis factor-α(TNF-α)and Apelin levels in patients with preeclampsia. Methods: 86 patients with preeclampsia who were treated in obstetrics and gynecology department of liaohe general hospital from October 2015 to August 2017 were selected. According to the severity of the patient’s condition, they were divided into mild preeclampsia group(46 cases) and severe preeclampsia group(40 cases). In addition, 40 healthy pregnant women in our hospital during the same period were selected as control group. The levels of APN, TNF-α, Apelin, low density lipoprotein cholesterol(LDL-C), triglyceride(TG), high density lipoprotein cholesterol(HDL-C) and total cholesterol(TC) of subjects in three groups were compared, and the correlation of serum APN, TNF-α, Apelin, LDL-C, TG, HDL-C and TC in patients with preeclampsia was also analyzed. Results: The level of serum APN in severe preeclampsia group was lower than that in mild preeclampsia group and control group, the levels of TNF-α and Apelin were significantly higher than those in mild preeclampsia group and control group(P<0.05). The level of serum APN in mild preeclampsia group was lower than that in the control group, and the levels of TNF-α, Apelin were higher than that in the control group(P<0.05). The levels of serum LDL-C, TG and TC in severe preeclampsia group were higher than those in mild preeclampsia group and control group, the level of HDL-C was lower than that in mild preeclampsia group and control group(P<0.05). The levels of LDL-C and TC in the mild preeclampsia group were higher than that in the control group, and the level of HDL-C was lower than that of the control group(P<0.05). The results of Pearson correlation analysis showed that the serum APN in patients with preeclampsia was negatively correlated with TNF-α, Apelin, LDL-C and TG, and it was positively correlated with HDL-C(P<0.05). TNF-α was positively correlated with Apelin, LDL-C, TG and TC, and it was negatively correlated with HDL-C(P<0.05).Apelin was positively correlated with LDL-C, TG and TC, and it was negatively correlated with HDL-C(P<0.05). Conclusion: The expression of serum APN in patients with preeclampsia is significantly decreased, and the expression of TNF-α and Apelin are significantly increased. The three indexes can affect each other, and they can affect the lipid metabolism level of the body, so as to regulate the disease progression in preeclampsia.